Granulomatous mycosis fungoides, a rare subtype of cutaneous T-cell lymphoma

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Granulomatous mycosis fungoides, a rare subtype of cutaneous T-cell lymphoma.

GMF: granulomatous mycosis fungoides INF-a: interferon alfa MF: mycosis fungoides TCR: T-cell receptor G ranulomatous mycosis fungoides (GMF) is an unusual histologic subtype of cutaneous T-cell lymphoma. The diagnosis of GMF is usually established after observation of a granulomatous inflammatory reaction associated with a malignant lymphoid infiltrate. Epidermotropism, a clue to diagnosis in ...

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Mycosis fungoides: cutaneous T-cell lymphoma.

Most patients with mycosis fungoides are between 40 and 60 years of age. The disease has three clinical stages: (1) the premycotic, or patch, stage, consisting of macular, scaling, faint pink to red pruritic patches, usually on unexposed surfaces; (2) the mycotic, or plaque, stage, consisting of reddish, purple-brown plaques, often annular in shape and symmetric in distribution, and (3) the tum...

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Cutaneous T-Cell Lymphoma (Mycosis Fungoides).

IT IS IMPORTANT YOU DO NOT ACCEPT THE DIRE PROGNOSIS given in older medical literature you may find in a public library. Patients diagnosed and treated at early stages of CTCL can usually expect to live a NORMAL LIFESPAN and die of unrelated causes. For others, however, relapses are common, and treatment must either be lifelong in order to control the disease, or it must be repeated each time a...

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Granulomatous slack skin: a rare subtype of mycosis fungoides*

We report a case of granulomatous slack skin, a rare and indolent subtype of mycosis fungoides. It affects mainly men between the third and fourth decades. It is characterized by hardened and erithematous plaques that mainly affect flexural areas and become pedunculated after some years. Histological examination shows a dense infiltrate of small atypical lymphocytes involving the dermis (and so...

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miR-223 regulates cell growth and targets proto-oncogenes in mycosis fungoides/cutaneous T-cell lymphoma

The pathogenesis of the cutaneous T-cell lymphoma (CTCL), mycosis fungoides (MF), is unclear. MicroRNA (miRNA) are small noncoding RNAs that target mRNA leading to reduced mRNA translation. Recently, specific miRNA were shown to be altered in CTCL. We detected significantly reduced expression of miR-223 in early-stage MF skin, and further decreased levels of miR-223 in advanced-stage disease. C...

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ژورنال

عنوان ژورنال: JAAD Case Reports

سال: 2015

ISSN: 2352-5126

DOI: 10.1016/j.jdcr.2015.05.010